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Recombinant Mouse Noggin (Carrier-free)
  • Recombinant Mouse Noggin (Carrier-free)

Recombinant Mouse Noggin (Carrier-free)

Cat No. Size Price Quantity
21-8004-U005 5 µg $76.00
21-8004-U020 20 µg $175.00
21-8004-U100 100 µg $675.00
21-8004-U500 500 µg $2,295.00

Description

Noggin is a highly conserved molecule and is a secreted protein that drives neural formation and dorsalization during embryonic development. It is also a BMP antagonist, biding BMP-4 as well as BMP-2 and BMP-7, to prevent them from associating with their receptors. Noggin is expressed in defined areas of the adult central nervous system and in various peripheral tissues such as lung, skeletal muscle, and skin.
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Noggin is a highly conserved molecule and is a secreted protein that drives neural formation and dorsalization during embryonic development. It is also a BMP antagonist, biding BMP-4 as well as BMP-2 and BMP-7, to prevent them from associating with their receptors. Noggin is expressed in defined areas of the adult central nervous system and in various peripheral tissues such as lung, skeletal muscle, and skin.
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Product Details

Name Recombinant Mouse Noggin (Carrier-free)
Cat. No. 21-8004
Alternative Names Nog
Amino Acid Sequence MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source E. coli
Reactivity Mouse
Research Areas Bone, Skeletal, Cartilage; Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.