Recombinant Mouse Neuropoietin (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7116-U005 | 5 µg | $76.00 | ||
| 21-7116-U025 | 25 µg | $179.00 | ||
| 21-7116-U100 | 100 µg | $725.00 | ||
| 21-7116-U500 | 500 µg | $2,295.00 |
Lead time: 2-3 business days
Technical Data Sheet
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Neuropoietin, also known as Cardiotrophin-2, is a secreted protein belonging to the IL-6 family of cytokines. It signals through a CNTF receptor complex consisting of CNTFR alpha, LIFR and gp130, resulting in the activation of the STAT3 pathway. Neuropoietin plays an important role in development of the nervous system. It has also been reported to sustain survival of motor neurons and affect adipogenesis and fat cell function. It is selectively expressed only during embryonic life, detected primarily in neuroepithelia and later in retina.
Neuropoietin, also known as Cardiotrophin-2, is a secreted protein belonging to the IL-6 family of cytokines. It signals through a CNTF receptor complex consisting of CNTFR alpha, LIFR and gp130, resulting in the activation of the STAT3 pathway. Neuropoietin plays an important role in development of the nervous system. It has also been reported to sustain survival of motor neurons and affect adipogenesis and fat cell function. It is selectively expressed only during embryonic life, detected primarily in neuroepithelia and later in retina.
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Product Details
| Name | Recombinant Mouse Neuropoietin (Carrier-free) |
|---|---|
| Cat. No. | 21-7116 |
| Alternative Names | NPO, NP, Ctf2, CT-2, Cardiotrophin-2 |
| Amino Acid Sequence | MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The dose-dependent stimulation of human TF-1 cell proliferation was used to determine an ED50 of 0.5-0.8 μg/ml. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Mouse Neuropoietin consists of 183 amino acids, generating a protein with a molecular weight of 19.8 kDa. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Mouse |
| Research Areas | Neurobiology |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.