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Recombinant Mouse Neuropoietin (Carrier-free)
  • Recombinant Mouse Neuropoietin (Carrier-free)

Recombinant Mouse Neuropoietin (Carrier-free)

Cat No. Size Price Quantity
21-7116-U005 5 µg $76.00
21-7116-U025 25 µg $179.00
21-7116-U100 100 µg $725.00
21-7116-U500 500 µg $2,295.00

Description

Neuropoietin, also known as Cardiotrophin-2, is a secreted protein belonging to the IL-6 family of cytokines. It signals through a CNTF receptor complex consisting of CNTFR alpha, LIFR and gp130, resulting in the activation of the STAT3 pathway. Neuropoietin plays an important role in development of the nervous system. It has also been reported to sustain survival of motor neurons and affect adipogenesis and fat cell function. It is selectively expressed only during embryonic life, detected primarily in neuroepithelia and later in retina.
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Neuropoietin, also known as Cardiotrophin-2, is a secreted protein belonging to the IL-6 family of cytokines. It signals through a CNTF receptor complex consisting of CNTFR alpha, LIFR and gp130, resulting in the activation of the STAT3 pathway. Neuropoietin plays an important role in development of the nervous system. It has also been reported to sustain survival of motor neurons and affect adipogenesis and fat cell function. It is selectively expressed only during embryonic life, detected primarily in neuroepithelia and later in retina.
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Product Details

Name Recombinant Mouse Neuropoietin (Carrier-free)
Cat. No. 21-7116
Alternative Names NPO, NP, Ctf2, CT-2, Cardiotrophin-2
Amino Acid Sequence MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The dose-dependent stimulation of human TF-1 cell proliferation was used to determine an ED50 of 0.5-0.8 μg/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse Neuropoietin consists of 183 amino acids, generating a protein with a molecular weight of 19.8 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.