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Recombinant Mouse M-CSF (Carrier-free)
  • Recombinant Mouse M-CSF (Carrier-free)

Recombinant Mouse M-CSF (Carrier-free)

Cat No. Size Price Quantity
21-8983-U002 2 µg $45.00
21-8983-U010 10 µg $89.00

Description

M-CSF is a hematopoietic growth factor that drives macrophage, monocyte, and bone marrow progenitor cell proliferation, differentiation, and survival. M-CSF increases macrophage and monocyte phagocytosis, chemotaxis, and tumoricidal activity making it an important therapeutic agent. M-CSF is used clinically for treatment of cancer, infectious diseases, and atherosclerosis. It is also used in recovery following bone marrow transplants. M-CSF is elaborated by multiple cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. M-CSF has also been associated with dermal thickening, pregnancy maintenance and female and male fertility.
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M-CSF is a hematopoietic growth factor that drives macrophage, monocyte, and bone marrow progenitor cell proliferation, differentiation, and survival. M-CSF increases macrophage and monocyte phagocytosis, chemotaxis, and tumoricidal activity making it an important therapeutic agent. M-CSF is used clinically for treatment of cancer, infectious diseases, and atherosclerosis. It is also used in recovery following bone marrow transplants. M-CSF is elaborated by multiple cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. M-CSF has also been associated with dermal thickening, pregnancy maintenance and female and male fertility.
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Product Details

Name Recombinant Mouse M-CSF (Carrier-free)
Cat. No. 21-8983
Alternative Names Macrophage Colony Stimulating Factor, CSF-1, MGI-IM
Amino Acid Sequence MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of M-NFS-60 cells is < 1.0 ng/ml, corresponding to a specific activity of ≥≥>1 x 106 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Cancer; Proliferation; Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.