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Recombinant Mouse IL-4 (Carrier-free)
  • Recombinant Mouse IL-4 (Carrier-free)

Recombinant Mouse IL-4 (Carrier-free)

Cat No. Size Price Quantity
21-8041-U005 5 µg $68.00
21-8041-U020 20 µg $183.00
21-8041-U100 100 µg $620.00
21-8041-U500 500 µg $1,995.00
Lead time: 2-3 business days

Description

IL-4 is a pleiotropic cytokine with major roles in the induction of Th2 cell differentiation and B cell Ig class switching. Additionally, IL-4 is involved in the development of allergic inflammation and asthma.

 

Recent Citations: 

Miki S, Suzuki JI, Takashima M, Ishida M, Kokubo H, Yoshizumi M. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469. doi: 10.1038/s41598-021-01866-3. PMID: 34789834; PMCID: PMC8599840.

» View on Nature

Tsurutani M, Horie H, Ogawa K. Cell Properties of Lung Tissue-Resident Macrophages Propagated by Co-Culture with Lung Fibroblastic Cells from C57BL/6 and BALB/c Mice. Biomedicines. 2021 Sep 16;9(9):1241. doi: 10.3390/biomedicines9091241. PMID: 34572425; PMCID: PMC8468995.

 » View on PubMed

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity. Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia ShapiroJohn A. Copland III, Taro Hitosugi, David Bernlohr, Jie Sun, Hu Zeng. bioRxiv 2020.04.22.028613; doi: https://doi.org/10.1101/2020.04.22.028613.

 » View on bioRxiv 

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on Journal of Immunology

View More
IL-4 is a pleiotropic cytokine with major roles in the induction of Th2 cell differentiation and B cell Ig class switching. Additionally, IL-4 is involved in the development of allergic inflammation and asthma.

 

Recent Citations: 

Miki S, Suzuki JI, Takashima M, Ishida M, Kokubo H, Yoshizumi M. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469. doi: 10.1038/s41598-021-01866-3. PMID: 34789834; PMCID: PMC8599840.

» View on Nature

Tsurutani M, Horie H, Ogawa K. Cell Properties of Lung Tissue-Resident Macrophages Propagated by Co-Culture with Lung Fibroblastic Cells from C57BL/6 and BALB/c Mice. Biomedicines. 2021 Sep 16;9(9):1241. doi: 10.3390/biomedicines9091241. PMID: 34572425; PMCID: PMC8468995.

 » View on PubMed

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity. Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia ShapiroJohn A. Copland III, Taro Hitosugi, David Bernlohr, Jie Sun, Hu Zeng. bioRxiv 2020.04.22.028613; doi: https://doi.org/10.1101/2020.04.22.028613.

 » View on bioRxiv 

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM and MacLeod AS. 2017. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. doi: 10.4049/jimmunol.1700739.

» View on Journal of Immunology

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Product Details

Name Recombinant Mouse IL-4 (Carrier-free)
Cat. No. 21-8041
Alternative Names BCGF, BCDF, B cell stimulating factor (BSF-1)
Amino Acid Sequence MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is < 2.0 ng/ml, corresponding to a specific activity of ≥≥>5 x 105 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Apoptosis; Cancer; Cell Culture; Immune System; Inflammation; Proliferation; Stem Cells & Differentiation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.