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Recombinant Mouse IL-33 (Carrier-free)
  • Recombinant Mouse IL-33 (Carrier-free)

Recombinant Mouse IL-33 (Carrier-free)

Cat No. Size Price Quantity
21-8332-U002 2 µg $69.00
21-8332-U010 10 µg $165.00
21-8332-U100 100 µg $875.00

Description

IL-33 is a nuclear factor (also known as NF-HEV) that shares structural and functional characteristics with the IL-1 family of cytokines. It is constitutively expressed in smooth muscle and airway epithelia, and expression in various cell types can be upregulated after stimulation with IL-1alpha or IL-1beta. The IL-33 inactive precursor protein is cleaved by caspase-1 and the resulting C-terminal fragment functions as mature, active protein. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases to induce Th2 associated cytokines.
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IL-33 is a nuclear factor (also known as NF-HEV) that shares structural and functional characteristics with the IL-1 family of cytokines. It is constitutively expressed in smooth muscle and airway epithelia, and expression in various cell types can be upregulated after stimulation with IL-1alpha or IL-1beta. The IL-33 inactive precursor protein is cleaved by caspase-1 and the resulting C-terminal fragment functions as mature, active protein. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases to induce Th2 associated cytokines.
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Product Details

Name Recombinant Mouse IL-33 (Carrier-free)
Cat. No. 21-8332
Alternative Names NF-HEV
Amino Acid Sequence SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Activity determine by proliferation of Mouse D10S calculated at <2 X 107 units/mg or .05 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse IL-33 is a 17.5 kDa protein containing 158 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Immune System; Inflammation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.