Recombinant Mouse GDNF (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8505-U002 | 2 µg | $76.00 | ||
| 21-8505-U010 | 10 µg | $179.00 | ||
| 21-8505-U100 | 100 µg | $1,025.00 | ||
| 21-8505-U500 | 500 µg | $2,900.00 |
Technical Data Sheet
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Glial Cell derived Neurotrophic Factor (GDNF) is a highly conserved neurotrophic factor. It is a novel member of the TGF-beta superfamily that has been shown to promote survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of development. Upregulated expression of GNDF was observed in various cancer cell lines and correlates with malignant cancer progression, suggesting a role of GDNF in carcinogenesis. The mature form of GDNF is a secreted protein that exists as a disulfide-linked homodimeric glycoprotein.
Glial Cell derived Neurotrophic Factor (GDNF) is a highly conserved neurotrophic factor. It is a novel member of the TGF-beta superfamily that has been shown to promote survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of development. Upregulated expression of GNDF was observed in various cancer cell lines and correlates with malignant cancer progression, suggesting a role of GDNF in carcinogenesis. The mature form of GDNF is a secreted protein that exists as a disulfide-linked homodimeric glycoprotein.
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Product Details
| Name | Recombinant Mouse GDNF (Carrier-free) |
|---|---|
| Cat. No. | 21-8505 |
| Alternative Names | Glial-Derived Neurotrophic Factor, ATF-1 |
| Amino Acid Sequence | MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The ED50 of ≤ 0.2 ng/ml corresponds to a specific activity of ≥ 5 x 106 units/mg, based on a proliferation assay using rat C6 cells. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Mouse GDNF has a calculated molecular weight of 30.4 kDa. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Mouse |
| Research Areas | Angiogenesis & Cardiovascular, Differentiation, Neurobiology, Stem Cells, TGF-beta Superfamily |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.