Recombinant Mouse CCL20 (MIP-3a) (Carrier-free)
  • Recombinant Mouse CCL20 (MIP-3a) (Carrier-free)

Recombinant Mouse CCL20 (MIP-3a) (Carrier-free)

Cat No. Size Price Quantity
21-8201-U005 5 µg $69.00
21-8201-U020 20 µg $172.00
21-8201-U100 100 µg $555.00
21-8201-U500 500 µg $1,525.00
Lead time: 2-3 business days

Description

MIP-3 alpha, or CCL20, is a member of the CC chemokine family. MIP-3 alpha is a ligand for CC chemokine receptor 6 (CCR6) and this interaction is responsible for the chemoattraction of immature dendritic cells (DC) and effector/memory T and B cells. Additionally, CCL20 plays a role in the function of mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. MIP-3 alpha is expressed mainly in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung tissue and is induced by LPS, TNF-α, IFN gamma, and other inflammatory mediators.
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MIP-3 alpha, or CCL20, is a member of the CC chemokine family. MIP-3 alpha is a ligand for CC chemokine receptor 6 (CCR6) and this interaction is responsible for the chemoattraction of immature dendritic cells (DC) and effector/memory T and B cells. Additionally, CCL20 plays a role in the function of mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. MIP-3 alpha is expressed mainly in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung tissue and is induced by LPS, TNF-α, IFN gamma, and other inflammatory mediators.
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Product Details

Name Recombinant Mouse CCL20 (MIP-3?) (Carrier-free)
Cat. No. 21-8201
Alternative Names Macrophage Inflammatory Protein-3 alpha, LARC, Exodus-1
Amino Acid Sequence ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to chemoattract Mouse CCR6 transfected HEK/293 cells using a concentration range of 0.1-10.0 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse MIP-3? is a 7.9 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Chemotaxis; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.