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Recombinant Mouse APRIL (Carrier-free)
  • Recombinant Mouse APRIL (Carrier-free)

Recombinant Mouse APRIL (Carrier-free)

Cat No. Size Price Quantity
21-8127-U005 5 µg $67.00
21-8127-U020 20 µg $180.00
21-8127-U100 100 µg $585.00
21-8127-U500 500 µg $1,841.00

Description

APRIL, an acronym for a proliferation inducing ligand is a TNF-α superfamily molecule. APRIL is expressed in myeloid cells, monocytes, and macrophages and appears to be involved in tumor cell regulation. It is highly expressed in certain transformed cell lines, certain colon carcinomas, and lymphoid tissues. APRIL enhances tumor cell proliferation. APRIL competes with BAFF for two common receptors, TACI and BCMA, and also binds proteoglycans. Like BAFF, APRIL also appears to have anti-apoptotic effects, enhances B cell and plasma cell survival and maintenance and shares other common effects.
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APRIL, an acronym for a proliferation inducing ligand is a TNF-α superfamily molecule. APRIL is expressed in myeloid cells, monocytes, and macrophages and appears to be involved in tumor cell regulation. It is highly expressed in certain transformed cell lines, certain colon carcinomas, and lymphoid tissues. APRIL enhances tumor cell proliferation. APRIL competes with BAFF for two common receptors, TACI and BCMA, and also binds proteoglycans. Like BAFF, APRIL also appears to have anti-apoptotic effects, enhances B cell and plasma cell survival and maintenance and shares other common effects.
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Product Details

Name Recombinant Mouse APRIL (Carrier-free)
Cat. No. 21-8127
Alternative Names
Amino Acid Sequence MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Assessed by induction of activated T cell proliferation.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Mouse APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Mouse
Research Areas Apoptosis; Cancer; Immune System; TNF-α Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.