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Recombinant Human TWEAK (CD255) (Carrier-free)
  • Recombinant Human TWEAK (CD255) (Carrier-free)

Recombinant Human TWEAK (CD255) (Carrier-free)

Cat No. Size Price Quantity
21-7089-U005 5 µg $76.00
21-7089-U025 25 µg $179.00
21-7089-U100 100 µg $585.00
21-7089-U500 500 µg $1,795.00

Description

The TNF-like weak inducer of apoptosis (TWEAK) cytokine belongs to the TNF-α superfamily of proteins that can exist in membrane bound or soluble formats. As its name suggests, it is not as effective in inducing apoptosis as TNF, and is limited to fewer cell targets. TWEAK can induce chemokine production, promote angiogenesis, and can induce proliferation and migration of endothelial cells. TWEAKR, alternatively known as FN14 or CD266, has been described as a receptor for TWEAK. DR3 (Death Receptor 3) has also been suggested as a receptor for TWEAK. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes.
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The TNF-like weak inducer of apoptosis (TWEAK) cytokine belongs to the TNF-α superfamily of proteins that can exist in membrane bound or soluble formats. As its name suggests, it is not as effective in inducing apoptosis as TNF, and is limited to fewer cell targets. TWEAK can induce chemokine production, promote angiogenesis, and can induce proliferation and migration of endothelial cells. TWEAKR, alternatively known as FN14 or CD266, has been described as a receptor for TWEAK. DR3 (Death Receptor 3) has also been suggested as a receptor for TWEAK. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes.
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Product Details

Name Recombinant Human TWEAK (CD255) (Carrier-free)
Cat. No. 21-7089
Alternative Names TNFRelated weak inducer of apoptosis, TNF-αSF12, DR3LG, Apo3-Ligand
Amino Acid Sequence MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Assay #1: The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/ml.
Assay #2: TWEAK weakly induces the death of HT29 cells when cul
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF-α homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Apoptosis; Inflammation; Neurobiology; Proliferation; TNF-α Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.