Recombinant Human TRANCE (sRANKL) (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8619-U002 | 2 µg | $71.00 | ||
| 21-8619-U010 | 10 µg | $189.00 | ||
| 21-8619-U100 | 100 µg | $945.00 | ||
| 21-8619-U500 | 500 µg | $2,675.00 |
Technical Data Sheet
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RANK L is a type II transmembrane protein belonging to the tumor necrosis factor family. RANK L is produced by osteoblasts and bone marrow stromal cells, is required for differentiation of osteoclasts, and stimulates bone resorption.
RANK L is a type II transmembrane protein belonging to the tumor necrosis factor family. RANK L is produced by osteoblasts and bone marrow stromal cells, is required for differentiation of osteoclasts, and stimulates bone resorption.
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Product Details
| Name | Recombinant Human TRANCE (sRANKL) (Carrier-free) |
|---|---|
| Cat. No. | 21-8619 |
| Alternative Names | soluble Receptor Activator of NFkB Ligand, TNF-αSF11, TRANCE (TNFRelated activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor) |
| Amino Acid Sequence | MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human sRANKL is a 20.0 kDa polypeptide comprising the TNF-α homologous region of RANKL (176 amino acid residues). |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Apoptosis; Bone, Skeletal, Cartilage; Immune System; TNF-α Superfamily |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.