Recombinant Human TIMP-2 (Carrier-free)
  • Recombinant Human TIMP-2 (Carrier-free)

Recombinant Human TIMP-2 (Carrier-free)

Cat No. Size Price Quantity
21-7086-U002 2 µg $76.00
21-7086-U010 10 µg $179.00
21-7086-U100 100 µg $955.00
Lead time: 2-3 business days

Description

Tissue Inhibitors of Metalloproteinase-2 (TIMP-2) is one of four TIMP proteins that functions as an endogenous inhibitor for the matrix metalloproteinases (MMPs). An imbalance between ≥ ≥ ≥ MMPs and their respective TIMPs can lead to various disease states. TIMP-2 is widely expressed in many mammalian tissues. It participates in functions including wound healing, angiogenesis, inflammatory responses and tumor metastasis. TIMP-2 can also act through an MMP-independent mechanism to regulate cell proliferation and demonstrates anti-angiogenic activities in vivo.
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Tissue Inhibitors of Metalloproteinase-2 (TIMP-2) is one of four TIMP proteins that functions as an endogenous inhibitor for the matrix metalloproteinases (MMPs). An imbalance between ≥ ≥ ≥ MMPs and their respective TIMPs can lead to various disease states. TIMP-2 is widely expressed in many mammalian tissues. It participates in functions including wound healing, angiogenesis, inflammatory responses and tumor metastasis. TIMP-2 can also act through an MMP-independent mechanism to regulate cell proliferation and demonstrates anti-angiogenic activities in vivo.
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Product Details

Name Recombinant Human TIMP-2 (Carrier-free)
Cat. No. 21-7086
Alternative Names Tissue inhibitor of metalloproteinases 2, CSC-21K
Amino Acid Sequence CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5 µg/ml, when using an MMP-1 co
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5 µg/ml, when using an MMP-1 co
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source E. coli
Reactivity Human
Research Areas Proliferation; Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.