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Recombinant Human TIMP-1 (Carrier-free)
  • Recombinant Human TIMP-1 (Carrier-free)

Recombinant Human TIMP-1 (Carrier-free)

Cat No. Size Price Quantity
21-7085-U002 2 µg $76.00
21-7085-U010 10 µg $179.00
21-7085-U100 100 µg $955.00
21-7085-U500 500 µg $2,860.00

Description

Tissue Inhibitors of Metalloproteinase-1 (TIMP-1) is one of four TIMP proteins that functions as an endogenous inhibitor for the matrix metalloproteinases (MMPs). An imbalance between ≥ ≥ ≥ MMPs and their respective TIMPs can lead to various disease states. TIMP-1 is widely expressed in many mammalian tissues, notably in the reproductive organs. It has a wide variety of roles, participating in functions including wound healing, angiogenesis, inflammatory responses and tumor metastasis. TIMP-1 appears to be the only of the four proteins that inhibit some MMPs less well than others – it is a poor inhibitor of MMP-19 and several MT-MMPs.
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Tissue Inhibitors of Metalloproteinase-1 (TIMP-1) is one of four TIMP proteins that functions as an endogenous inhibitor for the matrix metalloproteinases (MMPs). An imbalance between ≥ ≥ ≥ MMPs and their respective TIMPs can lead to various disease states. TIMP-1 is widely expressed in many mammalian tissues, notably in the reproductive organs. It has a wide variety of roles, participating in functions including wound healing, angiogenesis, inflammatory responses and tumor metastasis. TIMP-1 appears to be the only of the four proteins that inhibit some MMPs less well than others – it is a poor inhibitor of MMP-19 and several MT-MMPs.
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Product Details

Name Recombinant Human TIMP-1 (Carrier-free)
Cat. No. 21-7085
Alternative Names Tissue inhibitor of metalloproteinases, Fibroblast collagenase inhibitor, Erythroid-potentiating activity
Amino Acid Sequence CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 µg/ml, when using an MMP-1 con
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Inflammation; Proliferation; Stem Cells & Differentiation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.