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Recombinant Human Thrombopoietin (TPO) (Carrier-free)
  • Recombinant Human Thrombopoietin (TPO) (Carrier-free)

Recombinant Human Thrombopoietin (TPO) (Carrier-free)

Cat No. Size Price Quantity
21-8685-U002 2 µg $76.00
21-8685-U010 10 µg $175.00
21-8685-U100 100 µg $825.00
21-8685-U500 500 µg $2,495.00

Description

Thrombopoietin (TPO) is a growth factor that is involved in the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). TPO signals through the c-mpl (CD110) receptor, and acts as an important regulator of circulating platelets. TPO is produced in the liver and kidney.
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Thrombopoietin (TPO) is a growth factor that is involved in the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). TPO signals through the c-mpl (CD110) receptor, and acts as an important regulator of circulating platelets. TPO is produced in the liver and kidney.
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Product Details

Name Recombinant Human Thrombopoietin (TPO) (Carrier-free)
Cat. No. 21-8685
Alternative Names Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Amino Acid Sequence SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ? 1.0 ng/ml, corresponding to a specific activity of ≥ 1x 106 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Cell Culture; Proliferation; Stem Cells & Differentiation; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.