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Recombinant Human TGF-beta 2 (Carrier-free)
  • Recombinant Human TGF-beta 2 (Carrier-free)

Recombinant Human TGF-beta 2 (Carrier-free)

Cat No. Size Price Quantity
21-8478-U002 2 µg $76.00
21-8478-U010 10 µg $259.00
21-8478-U100 100 µg $1,250.00
21-8478-U500 500 µg $3,100.00

Description

Transforming Growth Factor beta 2 (TGF-beta 2) is a member of the TGF superfamily, and exists alongside 2 other mammalian isoforms of TGF-beta – TGF-beta 1 and TGF-beta 3 – which share a pair of receptors. All three isoforms are secreted by most cell types, and for regulatory control, must be activated before they exert functional activity. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. TGF-beta2 can induce differentiation, apoptosis, and angiogenesis.
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Transforming Growth Factor beta 2 (TGF-beta 2) is a member of the TGF superfamily, and exists alongside 2 other mammalian isoforms of TGF-beta – TGF-beta 1 and TGF-beta 3 – which share a pair of receptors. All three isoforms are secreted by most cell types, and for regulatory control, must be activated before they exert functional activity. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. TGF-beta2 can induce differentiation, apoptosis, and angiogenesis.
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Product Details

Name Recombinant Human TGF-beta 2 (Carrier-free)
Cat. No. 21-8478
Alternative Names Transforming Growth Factor-beta2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin
Amino Acid Sequence ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥≥ 5 x 106 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human TGF-beta 2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source HEK293 cells
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Apoptosis; Cancer; Immune System; Inflammation; Proliferation; Stem Cells & Differentiation; TGF-beta Superfamily; Wound Healing; Allergy
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.