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Recombinant Human sTRAIL Receptor 2 (Carrier-free)
  • Recombinant Human sTRAIL Receptor 2 (Carrier-free)

Recombinant Human sTRAIL Receptor 2 (Carrier-free)

Cat No. Size Price Quantity
21-7160-U010 10 µg $69.00
21-7160-U050 50 µg $175.00
21-7160-U100 100 µg $280.00
21-7160-U500 500 µg $859.00

Description

TRAIL Receptor 2 (DR5, TNFRSF10B, CD262, TRICK2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R2 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R2 expression can be induced by NF-kappaB.
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TRAIL Receptor 2 (DR5, TNFRSF10B, CD262, TRICK2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R2 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R2 expression can be induced by NF-kappaB.
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Product Details

Name Recombinant Human sTRAIL Receptor 2 (Carrier-free)
Cat. No. 21-7160
Alternative Names TRAIL R2, DR5, TNFRSF10B, CD262, ZTNFR9, TRICK2
Amino Acid Sequence MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ability to neutralize endogenous TRAIL in fresh human PBMC is measured through observing suppression of TRAIL-induced TNF-α production during a 24 hour exposure to 10 ng/ml of LPS.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human sTRAIL Receptor 2 is a 14.9 kDa protein consisting of 133 amino acids that correspond to the cysteine-rich extracellular domain.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas TNF-α Superfamily, Immune System, Cancer, Receptors
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.