Recombinant Human sTRAIL Receptor 2 (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7160-U010 | 10 µg | $69.00 | ||
| 21-7160-U050 | 50 µg | $175.00 | ||
| 21-7160-U100 | 100 µg | $280.00 | ||
| 21-7160-U500 | 500 µg | $859.00 |
Technical Data Sheet
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TRAIL Receptor 2 (DR5, TNFRSF10B, CD262, TRICK2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R2 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R2 expression can be induced by NF-kappaB.
TRAIL Receptor 2 (DR5, TNFRSF10B, CD262, TRICK2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R2 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R2 expression can be induced by NF-kappaB.
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Product Details
| Name | Recombinant Human sTRAIL Receptor 2 (Carrier-free) |
|---|---|
| Cat. No. | 21-7160 |
| Alternative Names | TRAIL R2, DR5, TNFRSF10B, CD262, ZTNFR9, TRICK2 |
| Amino Acid Sequence | MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The ability to neutralize endogenous TRAIL in fresh human PBMC is measured through observing suppression of TRAIL-induced TNF-α production during a 24 hour exposure to 10 ng/ml of LPS. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human sTRAIL Receptor 2 is a 14.9 kDa protein consisting of 133 amino acids that correspond to the cysteine-rich extracellular domain. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | TNF-α Superfamily, Immune System, Cancer, Receptors |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.