Recombinant Human sTRAIL Receptor 1 (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7159-U010 | 10 µg | $69.00 | ||
| 21-7159-U050 | 50 µg | $175.00 | ||
| 21-7159-U100 | 100 µg | $280.00 | ||
| 21-7159-U500 | 500 µg | $859.00 |
Technical Data Sheet
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TRAIL Receptor 1 (DR4, TNFRSF10A, CD261, APO2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R1 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R1 expression can be induced by NF-kappaB.
TRAIL Receptor 1 (DR4, TNFRSF10A, CD261, APO2) is a type I transmembrane protein belonging to the TNF-α receptor superfamily. It contains a cytoplasmic death domain and is one of the four receptors that bind TRAIL to initiate apoptosis. TRAIL R1 mediated apoptosis involves a signaling complex that includes FADD and caspases 8 and 10. TRAIL R1 expression can be induced by NF-kappaB.
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Product Details
| Name | Recombinant Human sTRAIL Receptor 1 (Carrier-free) |
|---|---|
| Cat. No. | 21-7159 |
| Alternative Names | TRAIL R1, DR4, TNFRSF10A, CD261, APO2 |
| Amino Acid Sequence | SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The expected ED50 is 0.4-0.5 ug/ml, as determined by measuring its ability to inhibit apoptosis in LN-18 cells. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human sTRAIL Receptor 1 is a 22.7 kDa protein consisting of ≥ 215 amino acids that correspond to the cysteine-rich extracellular domain. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | TNF-α Superfamily, Immune System, Cancer, Receptors |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.