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Recombinant Human sIL-6Ra (Carrier-free)
  • Recombinant Human sIL-6Ra (Carrier-free)

Recombinant Human sIL-6Ra (Carrier-free)

Cat No. Size Price Quantity
21-7109-U005 5 µg $69.00
21-7109-U020 20 µg $175.00
21-7109-U100 100 µg $565.00
21-7109-U500 500 µg $1,995.00

Description

The IL-6 receptor complex is made up of ≥ 2 subunits, IL-6R alpha (CD126) and the shared signaling receptor gp130. IL-6 first binds to the low-affinity IL-6R alpha, followed by association with gp130 which then transduces the signal. IL-6R alpha is expressed by many cells including fibroblasts, macrophages and T cells.
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The IL-6 receptor complex is made up of ≥ 2 subunits, IL-6R alpha (CD126) and the shared signaling receptor gp130. IL-6 first binds to the low-affinity IL-6R alpha, followed by association with gp130 which then transduces the signal. IL-6R alpha is expressed by many cells including fibroblasts, macrophages and T cells.
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Product Details

Name Recombinant Human sIL-6Rα? (Carrier-free)
Cat. No. 21-7109
Alternative Names soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126, IL-6R 1, membrane glycoprotein 80
Amino Acid Sequence LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RL
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ability to increase the IL-6 induced growth inhibition of murine M1 cells is measured. The expected ED50 for this effect, in the presence of ≥ 20 ng/ml recombinant human IL-6, is between ≥ ≥ ≥ 5.0 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human sIL-6Rα alpha is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R alpha chain (339 amino acid residues).
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source HEK293 cells
Reactivity Human
Research Areas Inflammation, Neurobiology, Receptors
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.