Recombinant Human Serpin F1 (PEDF) (Carrier-free)
  • Recombinant Human Serpin F1 (PEDF) (Carrier-free)

Recombinant Human Serpin F1 (PEDF) (Carrier-free)

Cat No. Size Price Quantity
21-7131-U005 5 µg $69.00
21-7131-U020 20 µg $175.00
21-7131-U100 100 µg $689.00
21-7131-U500 500 µg $2,295.00
Lead time: 2-3 business days

Description

Serpin F1, also known as PEDF, is a secreted glycoprotein that belongs to the clade F subfamily of the serpin family of proteinase inhibitors. Because it does not display any serine protease inhibitory activity it belongs to a second group, separate from other serpin family members that do possess typical protease inhibitor function. Serpin F1 is expressed in many tissues including lung, liver, skin, heart, and ovary, and it has diverse functions. These include anti-angiogenic, neuroprotective, and anti-carcinogenic activities. The protein has been mapped and different regions have been associated with its differing roles. It binds to the PEDF receptor and may have other receptor targets.
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Serpin F1, also known as PEDF, is a secreted glycoprotein that belongs to the clade F subfamily of the serpin family of proteinase inhibitors. Because it does not display any serine protease inhibitory activity it belongs to a second group, separate from other serpin family members that do possess typical protease inhibitor function. Serpin F1 is expressed in many tissues including lung, liver, skin, heart, and ovary, and it has diverse functions. These include anti-angiogenic, neuroprotective, and anti-carcinogenic activities. The protein has been mapped and different regions have been associated with its differing roles. It binds to the PEDF receptor and may have other receptor targets.
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Product Details

Name Recombinant Human Serpin F1 (PEDF) (Carrier-free)
Cat. No. 21-7131
Alternative Names Serine Proteinase Inhibitor-clade F1,PEDF (Pigment Epithelium-Derived Factor), EPC-1, PIG35
Amino Acid Sequence MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AV
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity No data available at this time.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Serpin F1 is a non-glycosylated protein of 400 amino acids, corresponding to a molecular weight of 44.5 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 90
Source E. coli
Reactivity Human
Research Areas Apoptosis, Angiogenesis & Cardiovascular, Cancer, Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.