Recombinant Human sDLL-4 (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7177-U005 | 5 µg | $76.00 | ||
| 21-7177-U025 | 25 µg | $175.00 | ||
| 21-7177-U100 | 100 µg | $585.00 | ||
| 21-7177-U500 | 500 µg | $1,750.00 |
Technical Data Sheet
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Delta-like protein 4 (DLL-4) is a type I transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL-4 activates through the Notch-1 and Notch-4 signaling pathways required in vascular development and homeostasis. In mice targeted deletion of the DLL-4 gene results in severe vascular defects and is lethal.
Delta-like protein 4 (DLL-4) is a type I transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL-4 activates through the Notch-1 and Notch-4 signaling pathways required in vascular development and homeostasis. In mice targeted deletion of the DLL-4 gene results in severe vascular defects and is lethal.
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Product Details
| Name | Recombinant Human sDLL-4 (Carrier-free) |
|---|---|
| Cat. No. | 21-7177 |
| Alternative Names | soluble DLL-4, Delta-like protein 4, Drosophila Delta homolog 4 |
| Amino Acid Sequence | SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NG |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The sDLL-4, when immobilized at concentrations >1.5 μg/ml, will inhibit myogenesis in C2C12 cells. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human sDLL-4 is the 54.3 kDa, 498 amino acid glycoprotein comprised of the extracellular signaling domain of the DLL-4 protein. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 95 |
| Source | HEK293 cells |
| Reactivity | Human |
| Research Areas | Angiogensis & Cardiovascular, Apoptosis, Cancer, Proliferation, Stem Cells & Differentiation |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.