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Recombinant Human Pleiotrophin (Carrier-free)
  • Recombinant Human Pleiotrophin (Carrier-free)

Recombinant Human Pleiotrophin (Carrier-free)

Cat No. Size Price Quantity
21-7123-U005 5 µg $76.00
21-7123-U020 20 µg $175.00
21-7123-U100 100 µg $585.00
21-7123-U500 500 µg $1,795.00

Description

The novel heparin-binding cytokine pleiotrophin (also known as HB-GAM) is a neurotrophic factor, structurally related to midkine. This protein is generally found in the central and peripheral nervous systems, and expression is highly regulated during development. Neurogenesis and cell migration are some of the proposed functions of pleiotrophin. Like midkine, it signals through the anaplastic lymphoma kinase (ALK) receptor leading to MAPK pathway activation. Pleiotrophin also associates with N-syndecan, enhancing axonal growth and neurite extension.
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The novel heparin-binding cytokine pleiotrophin (also known as HB-GAM) is a neurotrophic factor, structurally related to midkine. This protein is generally found in the central and peripheral nervous systems, and expression is highly regulated during development. Neurogenesis and cell migration are some of the proposed functions of pleiotrophin. Like midkine, it signals through the anaplastic lymphoma kinase (ALK) receptor leading to MAPK pathway activation. Pleiotrophin also associates with N-syndecan, enhancing axonal growth and neurite extension.
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Product Details

Name Recombinant Human Pleiotrophin (Carrier-free)
Cat. No. 21-7123
Alternative Names PTN, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8 (HBGF-8), Osteoblast-Specific Factor-1 (OSF-1), HBBN, HBNF-1, HB-GAM
Amino Acid Sequence GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Data currently unavailable.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Pleiotrophin consists of 136 amino acids, spanning 5 intra-molecular disulfide bonds. It has a molecular weight of 15.4 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.