Recombinant Human Persephin (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-7122-U005 | 5 µg | $76.00 | ||
| 21-7122-U020 | 20 µg | $175.00 | ||
| 21-7122-U100 | 100 µg | $585.00 | ||
| 21-7122-U500 | 500 µg | $1,795.00 |
Technical Data Sheet
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Persephin (PSP) is a secreted protein belonging to the family of neurotrophic factors that includes GDNF, neurturin (NTN) and artemin, all distantly related to the TGF-beta superfamily. Neurotrophic factors play in a role in development and maintenance of the nervous system. Persephin is reported to promote both the survival and growth of central dopaminergic and motor neurons, and kidney development, but does not support the peripheral nervous system. It is expressed at very low levels in many tissues. Persephin does not seem to signal through the same receptor complex as other family members GDNF and neurturin, but uses subunit GFR alpha-4 along with the receptor tyrosine kinase RET.
Persephin (PSP) is a secreted protein belonging to the family of neurotrophic factors that includes GDNF, neurturin (NTN) and artemin, all distantly related to the TGF-beta superfamily. Neurotrophic factors play in a role in development and maintenance of the nervous system. Persephin is reported to promote both the survival and growth of central dopaminergic and motor neurons, and kidney development, but does not support the peripheral nervous system. It is expressed at very low levels in many tissues. Persephin does not seem to signal through the same receptor complex as other family members GDNF and neurturin, but uses subunit GFR alpha-4 along with the receptor tyrosine kinase RET.
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Product Details
| Name | Recombinant Human Persephin (Carrier-free) |
|---|---|
| Cat. No. | 21-7122 |
| Alternative Names | PSP, PSPN |
| Amino Acid Sequence | RALSGPCQLW SLTLSVAELG LGYASEEKVI FRYCAGSCPR GARTQHGLAL ARLQGQGRAH GGPCCRPTRY TDVAFLDDRH RWQRLPQLSA AACGCGG |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Human Persephin binds to mammalian GFRa4 with a Kd of 100 pM and, within a concentration range of 0.1-1.0 ng/ml, induces RET phosphorylation. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human Persephin is a 194 amino acid disulfide-linked homodimer, composed of two 10.4 kDa polypeptide chains. Note: Licensed to manufacture by the University of Washington - patent numbers US 6,716,600; US 6,692,943; US 6,645,937; US 6,403,335; |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Neurobiology, TGF-beta Superfamily |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.