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Recombinant Human PDGF-AB (Carrier-free)
  • Recombinant Human PDGF-AB (Carrier-free)

Recombinant Human PDGF-AB (Carrier-free)

Cat No. Size Price Quantity
21-7119-U002 2 µg $69.00
21-7119-U010 10 µg $210.00
21-7119-U100 100 µg $750.00
21-7119-U500 500 µg $2,295.00

Description

Platelet-derived growth factor-AB (PDGF-AB) is one of the five dimeric proteins belonging to the PDGF family. Other members are homodimers PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD. The PDGFs are produced by platelets, stored in platelet alpha-granules and are released upon platelet activation. PDGF proteins are generally considered as potent mitogens for connective tissue cells, and can also be chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. PDGF-AB is reported to support angiogenesis in the heart. Two receptors have been identified for the PDGF proteins - PDGFR alpha and PDGFR beta. PDGF-AB is able to bind to both PDGFR alpha and PDGFR beta.
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Platelet-derived growth factor-AB (PDGF-AB) is one of the five dimeric proteins belonging to the PDGF family. Other members are homodimers PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD. The PDGFs are produced by platelets, stored in platelet alpha-granules and are released upon platelet activation. PDGF proteins are generally considered as potent mitogens for connective tissue cells, and can also be chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. PDGF-AB is reported to support angiogenesis in the heart. Two receptors have been identified for the PDGF proteins - PDGFR alpha and PDGFR beta. PDGF-AB is able to bind to both PDGFR alpha and PDGFR beta.
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Product Details

Name Recombinant Human PDGF-AB (Carrier-free)
Cat. No. 21-7119
Alternative Names Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
Amino Acid Sequence Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The expected ED50 is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1x 106 units/mg, as determined by the dose-dependent stimulation of BALB/c 3T3 cell proliferation.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human PDGF-AB is made up of one A and one B chain, resulting in a 26.4 kDa disulfide-linked heterodimer consisting of ≥ 234 total amino acids.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis & Cardiovascular, Bone and Cartilage, Cancer, Differentiation, Immune System, Neurobiology, Stem Cells, Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.