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Recombinant Human Neurturin (Carrier-free)
  • Recombinant Human Neurturin (Carrier-free)

Recombinant Human Neurturin (Carrier-free)

Cat No. Size Price Quantity
21-7118-U005 5 µg $76.00
21-7118-U020 20 µg $175.00
21-7118-U100 100 µg $585.00
21-7118-U500 500 µg $1,795.00

Description

Neurturin (NTN) is a secreted protein belonging to the family of neurotrophic factors that includes GDNF, persephin (PSP) and artemin, all distantly related to the TGF-beta superfamily. Similar to GDNF, neurturin is a secreted protein that exhibits strong trophic activity on dopaminergic neurons. It also promotes the development and survival of sympathetic and sensory neurons. Neurturin signals through the receptor tyrosine kinase (RET)/GFR-alpha 2 receptor complex, although it can also bind GFR-alpha 1 at higher concentrations.
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Neurturin (NTN) is a secreted protein belonging to the family of neurotrophic factors that includes GDNF, persephin (PSP) and artemin, all distantly related to the TGF-beta superfamily. Similar to GDNF, neurturin is a secreted protein that exhibits strong trophic activity on dopaminergic neurons. It also promotes the development and survival of sympathetic and sensory neurons. Neurturin signals through the receptor tyrosine kinase (RET)/GFR-alpha 2 receptor complex, although it can also bind GFR-alpha 1 at higher concentrations.
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Product Details

Name Recombinant Human Neurturin (Carrier-free)
Cat. No. 21-7118
Alternative Names NTN, NRTN, NTN6
Amino Acid Sequence ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity 100 ng/ml of recombinant human neurturin will support the survival of 65% of sympathetic neurons from newborn rat.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Neurturin is a disulfide-linked homodimer consisting of two 102 amino acid monomers of 11.8 kDa each.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Neurobiology, TGF-beta Superfamily
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.