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Recombinant Human Neuroserpin (Carrier-free)
  • Recombinant Human Neuroserpin (Carrier-free)

Recombinant Human Neuroserpin (Carrier-free)

Cat No. Size Price Quantity
21-7117-U005 5 µg $76.00
21-7117-U025 25 µg $175.00
21-7117-U100 100 µg $585.00
21-7117-U500 500 µg $1,795.00

Description

Neuroserpin, or Serpin I1, is a non-glycosylated inhibitory protein belonging to the serpin superfamily of serine proteinase inhibitors. This brain-associated protein inhibits the tissue-type plasminogen activator (tPA) enzyme. In the central nervous system, tPA is associated with synaptic plasticity and cell death. Neuroserpin expression patterns suggest a role in synaptogenesis. It is secreted by growth cones of neurons and is found predominantly in areas of the brain associated with memory and learning.
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Neuroserpin, or Serpin I1, is a non-glycosylated inhibitory protein belonging to the serpin superfamily of serine proteinase inhibitors. This brain-associated protein inhibits the tissue-type plasminogen activator (tPA) enzyme. In the central nervous system, tPA is associated with synaptic plasticity and cell death. Neuroserpin expression patterns suggest a role in synaptogenesis. It is secreted by growth cones of neurons and is found predominantly in areas of the brain associated with memory and learning.
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Product Details

Name Recombinant Human Neuroserpin (Carrier-free)
Cat. No. 21-7117
Alternative Names Serpin I1, Protease inhibitor 12, PI12
Amino Acid Sequence MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Using a concentration range of 0.3-0.6 μg/ml, activity is determined via a dose-dependent stimulation of rat C6 cell proliferation.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human Neuroserpin is a 395 amino acid protein with a molecular weight of 44.8 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 96
Source E. coli
Reactivity Human
Research Areas Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.