Recombinant Human/Mouse/Rat Myostatin (Carrier-Free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-9062-U002 | 2 µg | $80.00 | ||
| 21-9062-U010 | 10 µg | $195.00 | ||
| 21-9062-U050 | 50 µg | $624.00 | ||
| 21-9062-U100 | 100 µg | $1,040.00 |
Technical Data Sheet
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Myostatin is a TGF-Beta family member that acts as an inhibitor of skeletal muscle growth. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in Mouse, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of ≥ 243 amino acids.
Myostatin is a TGF-Beta family member that acts as an inhibitor of skeletal muscle growth. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in Mouse, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of ≥ 243 amino acids.
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Product Details
| Name | Recombinant Human/Mouse/Rat Myostatin (Carrier-Free) |
|---|---|
| Cat. No. | 21-9062 |
| Alternative Names | GDF-8 |
| Amino Acid Sequence | DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E.coli |
| Reactivity | Human |
| Research Areas | Proliferation, Angiogenesis/Cardiovascular, Diabetes/Weight Regulation, Bones, Skeletal, Cartilage |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.