Recombinant Human/Mouse/Rat GDF-11 (Carrier-Free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-9067-U005 | 5 µg | $80.00 | ||
| 21-9067-U020 | 20 µg | $195.00 | ||
| 21-9067-U100 | 100 µg | $780.00 | ||
| 21-9067-U500 | 500 µg | $2,340.00 |
Technical Data Sheet
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GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between ≥ ≥ ≥ myostatin and GDF-11 suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity.
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between ≥ ≥ ≥ myostatin and GDF-11 suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity.
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Product Details
| Name | Recombinant Human/Mouse/Rat GDF-11 (Carrier-Free) |
|---|---|
| Cat. No. | 21-9067 |
| Alternative Names | Growth/differentiation factor-11, BMP-11 |
| Amino Acid Sequence | NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E.coli |
| Reactivity | Human |
| Research Areas | Stem Cells & Differentiation, TGF-Beta Superfamily |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.