Recombinant Human M-CSF (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8789-U002 | 2 µg | $54.00 | ||
| 21-8789-U010 | 10 µg | $95.00 | ||
| 21-8789-U100 | 100 µg | $675.00 |
Lead time: 2-3 business days
Technical Data Sheet
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M-CSF, macrophage colony stimulating factor, is a hematopoietic growth factor important for driving differentiation, proliferation and maintenance of monocytes, macrophages, and other BM progenitor cells. M-CSF is produced by activated T cells and osteoclasts among other cell types. High levels of M-CSF in the pregnant uterus are associated with placenta formation and development. M-CSF activities include a variety of monocyte activities including enhanced phagocytic and chemotactic activity, and increased tumor cell cytotoxicity.
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Recent Citations:
Pawar K, Shigematsu M, Sharbati S, Kirino Y. Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7. PLoS Biol. 2020 Dec 17;18(12):e3000982. doi: 10.1371/journal.pbio.3000982. PMID: 33332353
M-CSF, macrophage colony stimulating factor, is a hematopoietic growth factor important for driving differentiation, proliferation and maintenance of monocytes, macrophages, and other BM progenitor cells. M-CSF is produced by activated T cells and osteoclasts among other cell types. High levels of M-CSF in the pregnant uterus are associated with placenta formation and development. M-CSF activities include a variety of monocyte activities including enhanced phagocytic and chemotactic activity, and increased tumor cell cytotoxicity.
Recent Citations:
Pawar K, Shigematsu M, Sharbati S, Kirino Y. Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7. PLoS Biol. 2020 Dec 17;18(12):e3000982. doi: 10.1371/journal.pbio.3000982. PMID: 33332353 HideProduct Details
| Name | Recombinant Human M-CSF (Carrier-free) |
|---|---|
| Cat. No. | 21-8789 |
| Alternative Names | Macrophage Colony Stimulating Factor, CSF-1, MGI-IM |
| Amino Acid Sequence | MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | ED50 determined by the dose-dependent stimulation of the proliferation of Mouse M-NSF-60 cells ? 1 ng/ml, corresponding to a specific activity of ≥1 x 106 units/mg. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human M-CSF is a 36.8 kDa homodimeric protein composed of two 159 amino acid polypeptide subunits. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Cancer; Proliferation; Stem Cells & Differentiation |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.