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Recombinant Human INSL5/INSL7 Hybrid (Carrier-free)
  • Recombinant Human INSL5/INSL7 Hybrid (Carrier-free)

Recombinant Human INSL5/INSL7 Hybrid (Carrier-free)

Cat No. Size Price Quantity
21-7110-U005 5 µg $76.00
21-7110-U025 25 µg $175.00
21-7110-U100 100 µg $585.00
21-7110-U500 500 µg $1,795.00

Description

At least seven relaxin-like proteins make up the Insulin/Relaxin superfamily. Most consist of two peptide subunits, an alpha-chain and a beta-chain, linked by disulfide bonds. INSL5 has been identified as the cognate ligand for the G-protein-coupled receptor GPCR142 (RXFP4). INSL7 (Relaxin-3) has been reported as a ligand for LGR7, as well as for GPCR135 and GPCR142. Sequence analysis indicates that INSL5 and INSL7 are highly homologous, but INSL5 seems to be specific only to GPCR142. The recombinant INSL5/INSL7 hybrid protein can activate the G protein coupled receptors GPCR135 and GPCR142, but unlike INSL7, does not induce significant activation of the LGR7 receptor.
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At least seven relaxin-like proteins make up the Insulin/Relaxin superfamily. Most consist of two peptide subunits, an alpha-chain and a beta-chain, linked by disulfide bonds. INSL5 has been identified as the cognate ligand for the G-protein-coupled receptor GPCR142 (RXFP4). INSL7 (Relaxin-3) has been reported as a ligand for LGR7, as well as for GPCR135 and GPCR142. Sequence analysis indicates that INSL5 and INSL7 are highly homologous, but INSL5 seems to be specific only to GPCR142. The recombinant INSL5/INSL7 hybrid protein can activate the G protein coupled receptors GPCR135 and GPCR142, but unlike INSL7, does not induce significant activation of the LGR7 receptor.
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Product Details

Name Recombinant Human INSL5/INSL7 Hybrid (Carrier-free)
Cat. No. 21-7110
Alternative Names H3, Relaxin-3, RXN3, ZINS4, insulin-like peptide INSL5, prepro-INSL5
Amino Acid Sequence A-chain: QDLQTLCCTD GCSMTDLSAL C B-chain: RAAPYGVRLC GREFIRAVIF TCGGSRW
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Data not available.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass The Recombinant Human INSL5/INSL7 hybrid consists of a 21 amino acid alpha-chain (INSL5) linked to a 27 amino acid beta-chain (INSL7) by two disulfide bonds and has a molecular weight of ≥ 5.2 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Diabetes, Lipid Metabolism, Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.