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Recombinant Human IL-6 (Carrier-free)
  • Recombinant Human IL-6 (Carrier-free)

Recombinant Human IL-6 (Carrier-free)

Cat No. Size Price Quantity
21-8069-U005 5 µg $67.00
21-8069-U020 20 µg $180.00
21-8069-U100 100 µg $565.00
21-8069-U500 500 µg $1,509.00

Description

IL-6 is a pleiotropic cytokine produced by a variety of cell types including T cells, monocytes, fibroblasts, endothelial cells and keratinocytes. IL-6 has diverse functions including important roles in the acute phase reaction, inflammation, hematopoiesis, and bone metabolism.

Recent Publications:

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Nishibayashi R, Inoue R, Harada Y, Watanabe T, Makioka Y and Ushida K. 2015. PLoS One. 10.1371/journal.pone.0129806 (Bioassay)

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IL-6 is a pleiotropic cytokine produced by a variety of cell types including T cells, monocytes, fibroblasts, endothelial cells and keratinocytes. IL-6 has diverse functions including important roles in the acute phase reaction, inflammation, hematopoiesis, and bone metabolism.

Recent Publications:

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216(6):1450-1464. doi:10.1084/jem.20182376.

» View on PubMed

Nishibayashi R, Inoue R, Harada Y, Watanabe T, Makioka Y and Ushida K. 2015. PLoS One. 10.1371/journal.pone.0129806 (Bioassay)

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Product Details

Name Recombinant Human IL-6 (Carrier-free)
Cat. No. 21-8069
Alternative Names 26 kDa protein, IFN-geta 2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
Amino Acid Sequence PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1x 107units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Cancer; Cell Culture; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Stem Cells & Differentiation; Wound Healing; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.