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Recombinant Human IL-4 (Carrier-free)
  • Recombinant Human IL-4 (Carrier-free)

Recombinant Human IL-4 (Carrier-free)

Cat No. Size Price Quantity
21-8044-U005 5 µg $67.00
21-8044-U020 20 µg $180.00
21-8044-U100 100 µg $620.00
21-8044-U500 500 µg $1,796.00

Description

IL-4 has diverse functions in regulating T and B cell responses. IL-4 is important in the differentiation of CD4+ cells into Th2 cells that produce IL-4, IL-5, IL-6, IL-10, and IL-1. IL-4 is produced by mast cells, T cells, basophils and bone marrow stromal cells. IL- 4 also drives B cell differentiation and Ig class switching especially to IgE producing cells highlighting IL-4 involvement in allergy.
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IL-4 has diverse functions in regulating T and B cell responses. IL-4 is important in the differentiation of CD4+ cells into Th2 cells that produce IL-4, IL-5, IL-6, IL-10, and IL-1. IL-4 is produced by mast cells, T cells, basophils and bone marrow stromal cells. IL- 4 also drives B cell differentiation and Ig class switching especially to IgE producing cells highlighting IL-4 involvement in allergy.
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Product Details

Name Recombinant Human IL-4 (Carrier-free)
Cat. No. 21-8044
Alternative Names BCGF, BCDF, B cell stimulating factor (BSF-1)
Amino Acid Sequence MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-4 is a 15.1 kDa composed of 130 amino acid residues
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Apoptosis; Cancer; Cell Culture; Immune System; Inflammation; Proliferation; Stem Cells & Differentiation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.