Recombinant Human IL-36ß (IL-1F8) (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8372-U002 | 2 µg | $69.00 | ||
| 21-8372-U010 | 10 µg | $179.00 | ||
| 21-8372-U100 | 100 µg | $995.00 | ||
| 21-8372-U500 | 500 µg | $2,995.00 |
Technical Data Sheet
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IL-36 beta, also known as IL-1F8, is a member of the IL-1 family of cytokines and binds to the IL-1R6 (IL-1Rrp2) receptor. It is reported to be expressed by resting and activated monocytes and B cells and at low levels in various tissues. It is highly expressed in psoriatic plaques. IL-36 beta displays pro-inflammatory effects and, like other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways.
IL-36 beta, also known as IL-1F8, is a member of the IL-1 family of cytokines and binds to the IL-1R6 (IL-1Rrp2) receptor. It is reported to be expressed by resting and activated monocytes and B cells and at low levels in various tissues. It is highly expressed in psoriatic plaques. IL-36 beta displays pro-inflammatory effects and, like other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways.
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Product Details
| Name | Recombinant Human IL-36β (IL-1F8) (Carrier-free) |
|---|---|
| Cat. No. | 21-8372 |
| Alternative Names | Interleukin-36β, IL-1F8, IL-1H2, IL-1 eta, FIL1 eta, family of interleukin 1-eta, FIL1H, Interleukin 1 Family 8 |
| Amino Acid Sequence | MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNF-αYL DSVE |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | The ability to induce IL-8 production by human PBMCs is measured. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human IL-36 beta contains 154 amino acid residues resulting in a 17.3 kDa protein. |
| Protein Content | Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 98 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Cancer, Diabetes, Immune System, Inflammation, Neurobiology, Proliferation |
| Reconstitution | See Certificate of Analysis (COA) for lot-specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.