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Recombinant Human IL-36RA (Carrier-free)
  • Recombinant Human IL-36RA (Carrier-free)

Recombinant Human IL-36RA (Carrier-free)

Cat No. Size Price Quantity
21-8374-U005 5 µg $69.00
21-8374-U025 25 µg $179.00
21-8374-U100 100 µg $569.00
21-8374-U500 500 µg $1,525.00

Description

IL-36 Receptor Antagonist (IL-36RA, also known as IL-1F5) belongs to the IL-1 family of cytokines. Binding to the IL-1Rrp2 receptor induces various activities including dendritic cell maturation and activation, and inhibits activity of ≥≥other IL-36 ctyokines, namely IL-36 alpha, beta and gamma. Cells reported to express IL-36Ra include monocytes, B cells, dendritic cells/Langerhans cells, keratinocytes, and gastric fundus parietal and chief cells. IL-36RA can antagonize the activation of NF-kappaB, induced by interleukin 1 family member 6 (IL1F6).
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IL-36 Receptor Antagonist (IL-36RA, also known as IL-1F5) belongs to the IL-1 family of cytokines. Binding to the IL-1Rrp2 receptor induces various activities including dendritic cell maturation and activation, and inhibits activity of ≥≥other IL-36 ctyokines, namely IL-36 alpha, beta and gamma. Cells reported to express IL-36Ra include monocytes, B cells, dendritic cells/Langerhans cells, keratinocytes, and gastric fundus parietal and chief cells. IL-36RA can antagonize the activation of NF-kappaB, induced by interleukin 1 family member 6 (IL1F6).
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Product Details

Name Recombinant Human IL-36RA (Carrier-free)
Cat. No. 21-8374
Alternative Names FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1
Amino Acid Sequence VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to inhibit IL-36 gamma induced IL-6 production by human PBMCs.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Cancer; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Proliferation; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.