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Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free)
  • Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free)

Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free)

Cat No. Size Price Quantity
21-8371-U002 2 µg $69.00
21-8371-U010 10 µg $199.00
21-8371-U100 100 µg $960.00

Description

IL-36 gamma (also known as IL-1F9) is a member of the IL-1 family of cytokines and binds to interleukin 1 receptor-like 2 (IL1RL2) and IL-1RAcP. IL-36 gamma displays proinflammatory effects and, along with the other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways. It is reported to be expressed in cells including Langerhans cells, keratinocytes/stratified squamos epithelium, chief cells, parietal cells and bronchial epithelial cells. Expression of IL­36 gamma in the skin is elevated through contact hypersensitivity and psoriasis, as well as inflammatory lung disorders (like asthma) and viral infections.
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IL-36 gamma (also known as IL-1F9) is a member of the IL-1 family of cytokines and binds to interleukin 1 receptor-like 2 (IL1RL2) and IL-1RAcP. IL-36 gamma displays proinflammatory effects and, along with the other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways. It is reported to be expressed in cells including Langerhans cells, keratinocytes/stratified squamos epithelium, chief cells, parietal cells and bronchial epithelial cells. Expression of IL­36 gamma in the skin is elevated through contact hypersensitivity and psoriasis, as well as inflammatory lung disorders (like asthma) and viral infections.
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Product Details

Name Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free)
Cat. No. 21-8371
Alternative Names IL-1F, IL-1epsilon, IL-1H1, IL36
Amino Acid Sequence SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to induce IL-8 production by human PBMCs.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IL-36 gamma is a 17.0 kDa protein containing 152 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source E. coli
Reactivity Human
Research Areas Cancer; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Proliferation; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.