Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8371-U002 | 2 µg | $69.00 | ||
| 21-8371-U010 | 10 µg | $199.00 | ||
| 21-8371-U100 | 100 µg | $960.00 |
Technical Data Sheet
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IL-36 gamma (also known as IL-1F9) is a member of the IL-1 family of cytokines and binds to interleukin 1 receptor-like 2 (IL1RL2) and IL-1RAcP. IL-36 gamma displays proinflammatory effects and, along with the other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways. It is reported to be expressed in cells including Langerhans cells, keratinocytes/stratified squamos epithelium, chief cells, parietal cells and bronchial epithelial cells. Expression of IL36 gamma in the skin is elevated through contact hypersensitivity and psoriasis, as well as inflammatory lung disorders (like asthma) and viral infections.
IL-36 gamma (also known as IL-1F9) is a member of the IL-1 family of cytokines and binds to interleukin 1 receptor-like 2 (IL1RL2) and IL-1RAcP. IL-36 gamma displays proinflammatory effects and, along with the other IL-36 cytokines, can activate NF-kB and MAPK signaling pathways. It is reported to be expressed in cells including Langerhans cells, keratinocytes/stratified squamos epithelium, chief cells, parietal cells and bronchial epithelial cells. Expression of IL36 gamma in the skin is elevated through contact hypersensitivity and psoriasis, as well as inflammatory lung disorders (like asthma) and viral infections.
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Product Details
| Name | Recombinant Human IL-36 gamma (IL-1F9) (Carrier-free) |
|---|---|
| Cat. No. | 21-8371 |
| Alternative Names | IL-1F, IL-1epsilon, IL-1H1, IL36 |
| Amino Acid Sequence | SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Measured by its ability to induce IL-8 production by human PBMCs. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant human IL-36 gamma is a 17.0 kDa protein containing 152 amino acid residues. |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 95 |
| Source | E. coli |
| Reactivity | Human |
| Research Areas | Cancer; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Proliferation; Wound Healing |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.