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Recombinant Human IL-34 (Carrier-free)
  • Recombinant Human IL-34 (Carrier-free)

Recombinant Human IL-34 (Carrier-free)

Cat No. Size Price Quantity
21-8684-U002 2 µg $69.00
21-8684-U010 10 µg $179.00
21-8684-U100 100 µg $885.00
21-8684-U500 500 µg $3,100.00

Description

IL-34 is secreted as a dimeric protein that is expressed in a variety of tissues, but is most abundant in the spleen. It shares the M-CSF Receptor, also known as CSF-1R and CD115, with CSF1 (also called M-CSF). IL-34 stimulates monocyte proliferation, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. It also stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.
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IL-34 is secreted as a dimeric protein that is expressed in a variety of tissues, but is most abundant in the spleen. It shares the M-CSF Receptor, also known as CSF-1R and CD115, with CSF1 (also called M-CSF). IL-34 stimulates monocyte proliferation, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. It also stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.
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Product Details

Name Recombinant Human IL-34 (Carrier-free)
Cat. No. 21-8684
Alternative Names C16orf77
Amino Acid Sequence NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Measured by its ability to induce secretion of MCP-1 from PBMCs.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source HEK293 cells
Reactivity Human
Research Areas Bone, Skeletal, Cartilage; Cancer; Immune System; Inflammation; Proliferation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.