Customer Service: (855) 848-6626 | 8:00 a.m - 4:30 p.m. PST | Save 35% on Ghost Dyes™

Recombinant Human IL-29/IFN-lambda1 (Carrier-free)
  • Recombinant Human IL-29/IFN-lambda1 (Carrier-free)

Recombinant Human IL-29/IFN-lambda1 (Carrier-free)

Cat No. Size Price Quantity
21-8298-U005 5 µg $76.00
21-8298-U020 20 µg $199.00
21-8298-U100 100 µg $585.00
21-8298-U500 500 µg $1,795.00

Description

The three members of this family, namely IFN-gambda1, -lambda2, and -lambda3 (also known as IL-29, IL-28A, and IL-28B) are part of the type III family of interferons. IL-29/IFN-g1 interacts with the heterodimeric cytokine receptor composed of IL10R2 and IFNLR1, expressed on epithelial cells and hepatocytes. Signaling through this receptor system induces antiviral activity similar but distinct from the type I Interferons. The type III interferons have been reported to induce dendritic cell-mediated expansion of Foxp3+ regulatory T cells.
View More
The three members of this family, namely IFN-gambda1, -lambda2, and -lambda3 (also known as IL-29, IL-28A, and IL-28B) are part of the type III family of interferons. IL-29/IFN-g1 interacts with the heterodimeric cytokine receptor composed of IL10R2 and IFNLR1, expressed on epithelial cells and hepatocytes. Signaling through this receptor system induces antiviral activity similar but distinct from the type I Interferons. The type III interferons have been reported to induce dendritic cell-mediated expansion of Foxp3+ regulatory T cells.
Hide

Product Details

Name Recombinant Human IL-29/IFN-gambda1 (Carrier-free)
Cat. No. 21-8298
Alternative Names Interferon lambda1, Interferon lamba 1
Amino Acid Sequence PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO 205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IFN-gambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Diabetes / Weight Regulation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.