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Recombinant Human IL-28A (IFN-lambda 2) (Carrier-free)
  • Recombinant Human IL-28A (IFN-lambda 2) (Carrier-free)

Recombinant Human IL-28A (IFN-lambda 2) (Carrier-free)

Cat No. Size Price Quantity
21-8363-U005 5 µg $76.00
21-8363-U020 20 µg $195.00
21-8363-U100 100 µg $615.00
21-8363-U500 500 µg $1,795.00

Description

IL-28A, also known as interferon lambda 2 (IFN-gambda2), is distantly related to type I interferons and the IL-10 family of cytokines. Along with IL-28B (IFN-gambda3) and IL-29 (IFN-gambda1), IL-28A belongs to the IFN-gambda family of type III interferons. Expression of the IFN-gabmda family of cytokines is triggered by virus infection. All three members bind to a receptor complex composed of an IFN-gambda R1 subunit (also called IL-28R alpha) and IL-10R2 subunit (also called IL-10R beta), inducing antiviral activity.
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IL-28A, also known as interferon lambda 2 (IFN-gambda2), is distantly related to type I interferons and the IL-10 family of cytokines. Along with IL-28B (IFN-gambda3) and IL-29 (IFN-gambda1), IL-28A belongs to the IFN-gambda family of type III interferons. Expression of the IFN-gabmda family of cytokines is triggered by virus infection. All three members bind to a receptor complex composed of an IFN-gambda R1 subunit (also called IL-28R alpha) and IL-10R2 subunit (also called IL-10R beta), inducing antiviral activity.
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Product Details

Name Recombinant Human IL-28A (IFN-gambda 2) (Carrier-free)
Cat. No. 21-8363
Alternative Names IFN-gambda2, interferon lambda-2, interferon lambda2, IL28A
Amino Acid Sequence PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO 205 cells. The expected ED50 is 0.3-0.5 ng/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IFN-g 2 is a 19.6 kDa protein containing 174 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Diabetes / Weight Regulation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.