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Recombinant Human IL-24 (Carrier-free)
  • Recombinant Human IL-24 (Carrier-free)

Recombinant Human IL-24 (Carrier-free)

Cat No. Size Price Quantity
21-7153-U005 5 µg $76.00
21-7153-U020 20 µg $175.00
21-7153-U100 100 µg $769.00
21-7153-U500 500 µg $2,295.00

Description

IL-24 belongs to the IL-10 cytokine family of structurally similar but functionally diverse members, and forms a subgroup with IL-19 and IL-20. It is expressed in B-cells, CD4+ T cells, NK cells, monocytes, lymph node dendritic cells and melanomas. IL-24 is shown to signal through two receptor complexes, IL-20Ra/IL-20Rb and IL-22R/IL-20Rb. Both receptor complexes are shared with other cytokines within the subgroup. Binding of receptors on endothelial cells activates STAT3 and blocks differentiation. IL-24 is able to selectively induce apoptosis in tumor cells at high concentrations, and at low concentrations it acts as a pro-inflammatory cytokine.
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IL-24 belongs to the IL-10 cytokine family of structurally similar but functionally diverse members, and forms a subgroup with IL-19 and IL-20. It is expressed in B-cells, CD4+ T cells, NK cells, monocytes, lymph node dendritic cells and melanomas. IL-24 is shown to signal through two receptor complexes, IL-20Ra/IL-20Rb and IL-22R/IL-20Rb. Both receptor complexes are shared with other cytokines within the subgroup. Binding of receptors on endothelial cells activates STAT3 and blocks differentiation. IL-24 is able to selectively induce apoptosis in tumor cells at high concentrations, and at low concentrations it acts as a pro-inflammatory cytokine.
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Product Details

Name Recombinant Human IL-24 (Carrier-free)
Cat. No. 21-7153
Alternative Names Interleukin-24, IL10B, MDA7, C49A, FISP, melanoma differentiation-associated gene 7 protein
Amino Acid Sequence QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVLQNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA NNFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTKALG EVDILLTWMQ KFYKLHHHHH H
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity No data available at this time.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-24 consists of 161 amino acids and is an 18.9 kDa glycoprotein that includes a C-terminal His-tag.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source CHO cells
Reactivity Human
Research Areas Cancer, Immune System, Proliferation, Apoptosis, Angiogenesis & Cardiovascular
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.