Recombinant Human IL-23 (Carrier-free)
| Cat No. | Size | Price | Quantity | |
|---|---|---|---|---|
| 21-8323-U002 | 2 µg | $88.00 | ||
| 21-8323-U010 | 10 µg | $249.00 | ||
| 21-8323-U100 | 100 µg | $1,750.00 | ||
| 21-8323-U500 | 500 µg | $5,985.00 |
Technical Data Sheet
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IL-23 is a disulfide-linked heterodimeric protein consisting of a p19 subunit unique to IL-23 and a p40 subunit that is shared with IL-12. IL-23 is proinflamatory and expressed by activated dendritic cells and macrophages. IL-23 drives the differentiation of Th17 cells in vivo and induces the proliferation of memory T cells.
IL-23 is a disulfide-linked heterodimeric protein consisting of a p19 subunit unique to IL-23 and a p40 subunit that is shared with IL-12. IL-23 is proinflamatory and expressed by activated dendritic cells and macrophages. IL-23 drives the differentiation of Th17 cells in vivo and induces the proliferation of memory T cells.
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Product Details
| Name | Recombinant Human IL-23 (Carrier-free) |
|---|---|
| Cat. No. | 21-8323 |
| Alternative Names | Toll-Like Receptor 4, ARMD10 |
| Amino Acid Sequence | p19 subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWT |
| Authenticity | Verified by N-terminal and Mass Spectrometry analyses (when applicable). |
| Bioactivity | Measured by its ability to induce IL-17 secretion by mouse splenocytes. |
| Endotoxin Level | Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg). |
| Molecular Mass | Recombinant Human IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids). |
| Protein Content | Content Verified by UV Spectroscopy and/or SDS-PAGE gel. |
| Purity (%) | 95 |
| Source | (BTI-Tn-5B1-4) Hi-5 Insect cells |
| Reactivity | Human |
| Research Areas | Cancer; Immune System; Inflammation; Allergy |
| Reconstitution | See Certificate of Analysis (COA) for lot specific reconstitution information. |
| Application | Bioassay |
Application Key:
FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.