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Recombinant Human IL-20 (Carrier-free)
  • Recombinant Human IL-20 (Carrier-free)

Recombinant Human IL-20 (Carrier-free)

Cat No. Size Price Quantity
21-7152-U002 2 µg $76.00
21-7152-U010 10 µg $179.00
21-7152-U100 100 µg $995.00
21-7152-U500 500 µg $2,995.00

Description

IL-20 belongs to the IL-10 cytokine family of structurally similar but functionally diverse members, and forms a subgroup with IL-19 and IL-24. IL-20 is produced by activated keratinocytes and monocytes. It regulates proliferation and differentiation in keratinocytes during inflammation. IL-20 is shown to signal through IL-20Ra/IL-20Rb (Type I) receptor complex, activating the STAT3 signaling pathway. IL-20 can also signal through an IL-20Rb/IL-22R (Type II) receptor complex. Both receptor complexes are shared with the other cytokines within the subgroup.
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IL-20 belongs to the IL-10 cytokine family of structurally similar but functionally diverse members, and forms a subgroup with IL-19 and IL-24. IL-20 is produced by activated keratinocytes and monocytes. It regulates proliferation and differentiation in keratinocytes during inflammation. IL-20 is shown to signal through IL-20Ra/IL-20Rb (Type I) receptor complex, activating the STAT3 signaling pathway. IL-20 can also signal through an IL-20Rb/IL-22R (Type II) receptor complex. Both receptor complexes are shared with the other cytokines within the subgroup.
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Product Details

Name Recombinant Human IL-20 (Carrier-free)
Cat. No. 21-7152
Alternative Names Interleukin-20, IL10D, Cytokine ZCYTO10
Amino Acid Sequence MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Following receptor-ligand interaction, the ability to activate STAT signaling is determined.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-20 is a homodimeric protein consisting of two 153 amino acid chains with a molecular weight of 35.2 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Allergy, Immune System, Inflammation, Proliferation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.