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Recombinant Human IL-2 (Carrier-free)
  • Recombinant Human IL-2 (Carrier-free)

Recombinant Human IL-2 (Carrier-free)

Cat No. Size Price Quantity
21-8029-U010 10 µg $125.00
21-8029-U050 50 µg $371.00
21-8029-U100 100 µg $565.00
21-8029-U500 500 µg $1,896.00

Description

IL-2 is a master immunoregulatory lymphokine produced by T cells in response to both antigen or mitogen activators. Signaling through the IL-2 receptor pathway is critical for T cell expansion and serves other requisite functions for normal immune response. IL-2 signals through the IL-2 receptor complex which shares a common gamma chain receptor for all other IL-2 related cytokines IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 also activates a spectrum of immune cells including B cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. IL-2 is a master cytokine and used widely in therapeutic regimens.
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IL-2 is a master immunoregulatory lymphokine produced by T cells in response to both antigen or mitogen activators. Signaling through the IL-2 receptor pathway is critical for T cell expansion and serves other requisite functions for normal immune response. IL-2 signals through the IL-2 receptor complex which shares a common gamma chain receptor for all other IL-2 related cytokines IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 also activates a spectrum of immune cells including B cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. IL-2 is a master cytokine and used widely in therapeutic regimens.
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Product Details

Name Recombinant Human IL-2 (Carrier-free)
Cat. No. 21-8029
Alternative Names T-cell growth factor (TCGF), Aldesleukin
Amino Acid Sequence MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1x 107 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-2 is a 15.5 kDa protein composed of 134 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas AIDS/HIV; Cancer; Cell Culture; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Proliferation; Stem Cells & Differentiation; Wound Healing; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.