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Recombinant Human IL-1RA (Carrier-free)
  • Recombinant Human IL-1RA (Carrier-free)

Recombinant Human IL-1RA (Carrier-free)

Cat No. Size Price Quantity
21-7070-U020 20 µg $76.00
21-7070-U100 100 µg $179.00
21-7070-U250 250 µg $360.00
21-7070-U500 500 µg $620.00

Description

Interleukin-1 receptor antagonist (IL-1RA) is a member of the IL-1 cytokine family of secreted proteins. It inhibits the activity of ≥≥IL-1? and IL-1beta by competitively blocking their binding to type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.
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Interleukin-1 receptor antagonist (IL-1RA) is a member of the IL-1 cytokine family of secreted proteins. It inhibits the activity of ≥≥IL-1? and IL-1beta by competitively blocking their binding to type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.
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Product Details

Name Recombinant Human IL-1RA (Carrier-free)
Cat. No. 21-7070
Alternative Names IL-1RA, ICIL-1RA, IRAP, IL-1RN
Amino Acid Sequence MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit the IL-1 alpha stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of ≥ 50 pg/ml of IL-1 alpha.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Diabetes / Weight Regulation; Inflammation; Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.