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Recombinant Human IL-1a (Carrier-free)
  • Recombinant Human IL-1a (Carrier-free)

Recombinant Human IL-1a (Carrier-free)

Cat No. Size Price Quantity
21-8019-U002 2 µg $69.00
21-8019-U010 10 µg $195.00
21-8019-U100 100 µg $855.00
21-8019-U500 500 µg $2,210.00

Description

IL-1 alpha, a member of the IL-1 family, is a non-secreted proinflamatory cytokine involved in the promotion of fever and sepsis. This cytokine is primarily produced by activated macrophages in addition to neutrophils, epithelial and endothelial cells. It is known to induce proliferation in vascular smooth muscle cells, it is involved in T cell activation, and it stimulates thymocyte proliferation.
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IL-1 alpha, a member of the IL-1 family, is a non-secreted proinflamatory cytokine involved in the promotion of fever and sepsis. This cytokine is primarily produced by activated macrophages in addition to neutrophils, epithelial and endothelial cells. It is known to induce proliferation in vascular smooth muscle cells, it is involved in T cell activation, and it stimulates thymocyte proliferation.
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Product Details

Name Recombinant Human IL-1α (Carrier-free)
Cat. No. 21-8019
Alternative Names Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Amino Acid Sequence SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1x 109 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-1? is a 18.0 kDa protein composed 159 amino acid residues.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Cancer; Diabetes / Weight Regulation; Immune System; Inflammation; Neurobiology; Proliferation; Stem Cells & Differentiation; Wound Healing; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.