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Recombinant Human IL-17F (Carrier-free)
  • Recombinant Human IL-17F (Carrier-free)

Recombinant Human IL-17F (Carrier-free)

Cat No. Size Price Quantity
21-8479-U005 5 µg $75.00
21-8479-U025 25 µg $180.00
21-8479-U100 100 µg $525.00
21-8479-U500 500 µg $1,595.00

Description

IL-17F is one of 6 isoforms of the IL-17 family. IL-17F has been shown to be important in inflammatory responses accompanying asthma. IL-17F binds to IL-17RA and IL-17RC receptor isoforms and activates through the MAP kinase pathway. IL-17F is produced by several immune cell lineages including Th17 cells, mast cells, and basophils. Like the entire IL-17 family, IL-17F is implicated in autoimmune inflammatory disease pathogenesis resulting from dysregulated or unmitigated inflammation processes.
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IL-17F is one of 6 isoforms of the IL-17 family. IL-17F has been shown to be important in inflammatory responses accompanying asthma. IL-17F binds to IL-17RA and IL-17RC receptor isoforms and activates through the MAP kinase pathway. IL-17F is produced by several immune cell lineages including Th17 cells, mast cells, and basophils. Like the entire IL-17 family, IL-17F is implicated in autoimmune inflammatory disease pathogenesis resulting from dysregulated or unmitigated inflammation processes.
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Product Details

Name Recombinant Human IL-17F (Carrier-free)
Cat. No. 21-8479
Alternative Names
Amino Acid Sequence MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to induce IL-6 production by NHDF cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-17F is a disulfide-linked homodimer of 30.1 kDa and composed of two 133 amino acid residue chains.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Immune System; Proliferation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.