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Recombinant Human IL-17A (Carrier-free)
  • Recombinant Human IL-17A (Carrier-free)

Recombinant Human IL-17A (Carrier-free)

Cat No. Size Price Quantity
21-8179-U005 5 µg $75.00
21-8179-U025 25 µg $180.00
21-8179-U100 100 µg $525.00
21-8179-U500 500 µg $1,595.00

Description

IL-17A is elaborated and secreted by neutrophils and T lymphocytes expressing the Th17 lineage-specific transcription factor Retinoic acid receptor-related orphan receptor ?t. It is induced by IL-23. IL-17A is a cytokine that acts as a potent pro-inflammatory mediator that recruits monocytes and neutrophils to inflammatory sites much like Interferon gamma. IL-17 acts synergistically with other inflammatory mediators such as TNF-αα and IL-1.
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IL-17A is elaborated and secreted by neutrophils and T lymphocytes expressing the Th17 lineage-specific transcription factor Retinoic acid receptor-related orphan receptor ?t. It is induced by IL-23. IL-17A is a cytokine that acts as a potent pro-inflammatory mediator that recruits monocytes and neutrophils to inflammatory sites much like Interferon gamma. IL-17 acts synergistically with other inflammatory mediators such as TNF-αα and IL-1.
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Product Details

Name Recombinant Human IL-17A (Carrier-free)
Cat. No. 21-8179
Alternative Names IL-17, CTLA-8
Amino Acid Sequence MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Within a concentration range of 0.5-1.5 ng/ml, the ability to induce IL-6 production by NHDF cells is measured.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass This recombinant proteins is a disulfide-linked homodimer of two 137 amino acid polypeptide chains with 31.3 kDa molecualr weight.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas AIDS/HIV; Angiogenesis/Cardiovascular; Immune System?;? Inflammation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.