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Recombinant Human IL-16 (121 a.a.) (Carrier-free)
  • Recombinant Human IL-16 (121 a.a.) (Carrier-free)

Recombinant Human IL-16 (121 a.a.) (Carrier-free)

Cat No. Size Price Quantity
21-7151-U002 2 µg $76.00
21-7151-U010 10 µg $179.00
21-7151-U100 100 µg $995.00
21-7151-U500 500 µg $2,995.00

Description

IL-16 is an immunomodulatory cytokine secreted by activated CD8+ T cells, as well as other immune and non-immune cell types. It serves as a chemoattractant for CD4+ T cells, macrophages, and eosinophils. IL-16 induces expression of CD25 (IL-2R) and plays a role in the accumulation and activation of CD4+ cells recruited to sites of inflammation. IL-16 (121 a.a.) is a proteolytic product of pro-IL-16 cleaved by Caspase-3 after T-cell activation, producing a secreted biologically active form. It requires surface CD4 to mediate signaling processes.
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IL-16 is an immunomodulatory cytokine secreted by activated CD8+ T cells, as well as other immune and non-immune cell types. It serves as a chemoattractant for CD4+ T cells, macrophages, and eosinophils. IL-16 induces expression of CD25 (IL-2R) and plays a role in the accumulation and activation of CD4+ cells recruited to sites of inflammation. IL-16 (121 a.a.) is a proteolytic product of pro-IL-16 cleaved by Caspase-3 after T-cell activation, producing a secreted biologically active form. It requires surface CD4 to mediate signaling processes.
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Product Details

Name Recombinant Human IL-16 (121 a.a.) (Carrier-free)
Cat. No. 21-7151
Alternative Names Interleukin-16, LCF, Lymphocyte Chemoattractant Factor
Amino Acid Sequence SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity A concentration range of ≥ 50-100 ng/ml is used to measure the ability to chemoattract human CD4+ T lymphocytes.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-16 consists of 121 amino acids and is a 12.4 kDa protein.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Immune System, AIDS, Inflammation, Apoptosis
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.