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Recombinant Human IL-13 Variant (Carrier-free)
  • Recombinant Human IL-13 Variant (Carrier-free)

Recombinant Human IL-13 Variant (Carrier-free)

Cat No. Size Price Quantity
21-7150-U002 2 µg $76.00
21-7150-U010 10 µg $179.00
21-7150-U100 100 µg $995.00
21-7150-U500 500 µg $2,995.00

Description

IL-13, produced primarily by Th2 cells and to a lesser extent by mast and NK cells, is an immunoregulatory cytokine. Its various functions include induction of matrix metalloproteinases, enhancement of IgE secretion from activated B cells and B cell proliferation. Additionally, IL-13 plays a role in the inhibition of the expression of inflammatory cytokines and modulates resistance to various parasites. IL-13 is also secreted by eosinophils and in the lung is essential in regulating eosinophilic inflammation, mucus secretion, and airway hyperresponsiveness. Its function as a central mediator of allergen-induced asthma is well documented. Single nucleotide polymorphisms result in variants associated with specific asthmatic or allergic phenotypes, and certain variants will show enhanced functional activity as compared to wild-type IL-13.
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IL-13, produced primarily by Th2 cells and to a lesser extent by mast and NK cells, is an immunoregulatory cytokine. Its various functions include induction of matrix metalloproteinases, enhancement of IgE secretion from activated B cells and B cell proliferation. Additionally, IL-13 plays a role in the inhibition of the expression of inflammatory cytokines and modulates resistance to various parasites. IL-13 is also secreted by eosinophils and in the lung is essential in regulating eosinophilic inflammation, mucus secretion, and airway hyperresponsiveness. Its function as a central mediator of allergen-induced asthma is well documented. Single nucleotide polymorphisms result in variants associated with specific asthmatic or allergic phenotypes, and certain variants will show enhanced functional activity as compared to wild-type IL-13.
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Product Details

Name Recombinant Human IL-13 Variant (Carrier-free)
Cat. No. 21-7150
Alternative Names Interleukin 13, NC30
Amino Acid Sequence MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Compared to wild type IL-13, this variant shows a two fold increase in bioactivity both in vitro and in vivo. Dose dependent STAT6 activation and IL-13 dependent gene induction in transfected A201.1 cells were used to demonstrate this difference in vitro.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant Human IL-13 Variant, with a substitution of Q for R at position 112, consists of 115 amino acids and a calculated molecular weight of 12.6 kDa.
Protein Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Immune System, AIDS, Inflammation, Cancer, Differentiation, Stem Cells
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.