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Recombinant Human IL-10 (Carrier-free)
  • Recombinant Human IL-10 (Carrier-free)

Recombinant Human IL-10 (Carrier-free)

Cat No. Size Price Quantity
21-8109-U002 2 µg $61.00
21-8109-U010 10 µg $175.00
21-8109-U100 100 µg $1,050.00
21-8109-U500 500 µg $2,560.00
Lead time: 2-3 business days

Description

IL-10 is elaborated and secreted by macrophages, monocytes, T cells, B cells and keratinocytes and is well characterized as a potent immunosuppressive and anti-inflammatory cytokine. IL-10 has been shown to exert inhibitory effects on Th0, Th1 and Th2 subsets and monocytes. IL-10 has been shown also to inhibit expression of co-stimulatory molecules such as CD80 and CD86 on antigen presenting cells. IL-10 has also been shown to enhance B-cell and other responses in specific scenarios. Because of its pleiotropic role, IL-10 has been explored as a therapeutic agent in inflammatory diseases and cancer.
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IL-10 is elaborated and secreted by macrophages, monocytes, T cells, B cells and keratinocytes and is well characterized as a potent immunosuppressive and anti-inflammatory cytokine. IL-10 has been shown to exert inhibitory effects on Th0, Th1 and Th2 subsets and monocytes. IL-10 has been shown also to inhibit expression of co-stimulatory molecules such as CD80 and CD86 on antigen presenting cells. IL-10 has also been shown to enhance B-cell and other responses in specific scenarios. Because of its pleiotropic role, IL-10 has been explored as a therapeutic agent in inflammatory diseases and cancer.
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Product Details

Name Recombinant Human IL-10 (Carrier-free)
Cat. No. 21-8109
Alternative Names B-TCGF, CSIF, TGIF
Amino Acid Sequence MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was found to be 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass This recombinant protein is 161 amino acid residues with a molecular weight of 18.6 kDa.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas AIDS/HIV; Cancer; Immune System; Inflammation; Neurobiology; Stem Cells & Differentiation; Allergy; Transplantation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.