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Recombinant Human IGF-I (Carrier-free)
  • Recombinant Human IGF-I (Carrier-free)

Recombinant Human IGF-I (Carrier-free)

Cat No. Size Price Quantity
21-7068-U100 100 µg $76.00
21-7068-U500 500 µg $189.00
21-7068-M001 1 mg $280.00

Description

IGF-I (insulin-like growth factor 1) is a hormone similar to insulin in structure and function, and is a member of a family of proteins involved in mediating growth and development. IGF-I expression is regulated by growth hormone, is expressed in many cell and tissue types including liver, and may have autocrine, paracrine and endocrine functions. IGF-I binds to 3 receptors – IGF-I R, IGF-II R and the insulin receptor, and binding to IGF-I R promotes cell proliferation, survival, differentiation, and migration. Association with IGF binding proteins acts to extend the half-life of IGF-I and regulates receptor interaction.
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IGF-I (insulin-like growth factor 1) is a hormone similar to insulin in structure and function, and is a member of a family of proteins involved in mediating growth and development. IGF-I expression is regulated by growth hormone, is expressed in many cell and tissue types including liver, and may have autocrine, paracrine and endocrine functions. IGF-I binds to 3 receptors – IGF-I R, IGF-II R and the insulin receptor, and binding to IGF-I R promotes cell proliferation, survival, differentiation, and migration. Association with IGF binding proteins acts to extend the half-life of IGF-I and regulates receptor interaction.
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Product Details

Name Recombinant Human IGF-I (Carrier-free)
Cat. No. 21-7068
Alternative Names insulin-like growth factor 1
Amino Acid Sequence GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ? 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IGF-I is a globular protein containing 70 amino acids and 3 intra-molecular disulfide bonds.
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation; Proliferation; Wound Healing
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.