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Recombinant Human IGF-BP6 (Carrier-free)
  • Recombinant Human IGF-BP6 (Carrier-free)

Recombinant Human IGF-BP6 (Carrier-free)

Cat No. Size Price Quantity
21-7067-U020 20 µg $175.00
21-7067-U100 100 µg $825.00
21-7067-U500 500 µg $3,100.00
21-7067-U005 5 µg $76.00

Description

Insulin-like growth factor binding proteins (IGF-BPs) are a family of secreted proteins with conserved amino- and carboxy-terminal sequences and variable mid-regions. IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP6 is found in serum, ovary, prostate, fibroblasts and cerebral spinal fluid, and has a preference for binding IGF II over IGF I. IGFBP-6 also has IGF-independent effects, including inhibition of angiogenesis and promotion of cancer cell migration.
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Insulin-like growth factor binding proteins (IGF-BPs) are a family of secreted proteins with conserved amino- and carboxy-terminal sequences and variable mid-regions. IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP6 is found in serum, ovary, prostate, fibroblasts and cerebral spinal fluid, and has a preference for binding IGF II over IGF I. IGFBP-6 also has IGF-independent effects, including inhibition of angiogenesis and promotion of cancer cell migration.
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Product Details

Name Recombinant Human IGF-BP6 (Carrier-free)
Cat. No. 21-7067
Alternative Names IBP-6, Insulin-like Growth Factor-Binding Protein 6
Amino Acid Sequence RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRREG QECGVYTPNCA PGLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNGS SSCPTGSSG
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 - 0.4 µg/ml.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IGF-BP6 has a calculated mass of ≥ 22.6 kDa and consists of ≥ 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE an
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 95
Source (BTI-Tn-5B1-4) Hi-5 Insect cells*
Reactivity Human
Research Areas Apoptosis; Cancer; Diabetes / Weight Regulation; Proliferation; Neurobiology
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.