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Recombinant Human IGF-BP1 (Carrier-free)
  • Recombinant Human IGF-BP1 (Carrier-free)

Recombinant Human IGF-BP1 (Carrier-free)

Cat No. Size Price Quantity
21-7066-U005 5 µg $76.00
21-7066-U025 25 µg $175.00
21-7066-U100 100 µg $585.00
21-7066-U500 500 µg $1,795.00

Description

Insulin-like growth factor binding proteins (IGF-BPs) are a family of secreted proteins with conserved amino- and carboxy-terminal sequences and variable mid-regions. IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP1 is expressed in serum, liver, decidua, kidneys and amniotic fluid, and binds to IGFs I and II. Phosphorylated IGF-BP1 hinders IGF actions, whereas nonphosphorylated IGF-BP1 is stimulatory. Insulin and corticosteroids affect hepatocyte production of IGF-BP1.
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Insulin-like growth factor binding proteins (IGF-BPs) are a family of secreted proteins with conserved amino- and carboxy-terminal sequences and variable mid-regions. IGF-BPs control the distribution, function and activity of ≥≥IGFs in various cell tissues and body fluids. IGF-BP1 is expressed in serum, liver, decidua, kidneys and amniotic fluid, and binds to IGFs I and II. Phosphorylated IGF-BP1 hinders IGF actions, whereas nonphosphorylated IGF-BP1 is stimulatory. Insulin and corticosteroids affect hepatocyte production of IGF-BP1.
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Product Details

Name Recombinant Human IGF-BP1 (Carrier-free)
Cat. No. 21-7066
Alternative Names Insulin-like Growth Factor-Binding Protein 1, IBP-1, Placenta Protein 12 (PP12)
Amino Acid Sequence MAPWQCAPCS AEKLALCPPV SASCSEVTRS AGCGCCPMCA LPLGAACGVA TARCARGLSC RALPGEQQPL HALTRGQGAC VQESDASAPH AAEAGSPESP ESTEITEEEL LDNFHLMAPS EEDHSILWDA ISTYDGSKAL HVTNIKKWKE PCRIELYRVV ESLAKAQETS GEEISKFYLP NCNKNGFYHS RQCETSMDGE AGLCWCVYPW NGKRIPGSPE IRGDPNCQIY FN
Authenticity Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity The ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is ≤ 0.5 µg/ml in the presence of 6 ng/ml of human IGF-I.
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Molecular Mass Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of ≥ 235 amino acid residues (Isoform A).
Protein Content Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Purity (%) 98
Source E. coli
Reactivity Human
Research Areas Apoptosis; Cancer; Diabetes / Weight Regulation; Proliferation
Reconstitution See Certificate of Analysis (COA) for lot specific reconstitution information.
Application Bioassay
Application Key:

FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.